GHK

GHK-Cu is a naturally occurring copper-binding tripeptide (Glycyl-L-Histidyl-L-Lysine) first isolated from human plasma. It is a metallopeptide with a high affinity for divalent copper ions (Cu2+), forming a stable complex that functions as a primary modulator of tissue remodeling. GHK-Cu operates as a feedback signal for tissue injury by activating the extracellular matrix (ECM), upregulating the synthesis of collagen, elastin, and glycosaminoglycans. Research applications include investigations into wound healing acceleration, angiogenic signaling (via VEGF induction), and the modulation of gene expression related to antioxidant defense and cellular senescence.

Properties

• Amino Acid Sequence: Gly-His-Lys (complexed with Copper II)
• Chemical Formula: C14H22CuN6O4
• Molar Mass: 401.91 g/mol
• CAS Number: 89030-95-5 (Cu complex) / 49557-75-7 (GHK)
• Synonyms: Copper Tripeptide-1, Prezatide Copper, Glycyl-L-histidyl-L-lysine copper