F0X04 10

Analytical Reagent FX-04 is a synthetic D-Retro-Inverso (DRI) isoform peptide designed to investigate the p53-FOXO4 interaction within cellular models of senescence. By functioning as a competitive antagonist for the FOXO4 transcription factor, this reagent is used in laboratory settings to study the induction of apoptosis in senescent cell populations and the modulation of the SASP (Senescence-Associated Secretory Phenotype). Research focus involves the interrogation of cellular proteostasis and the investigation of mitochondrial-mediated apoptotic pathways in vitro.

Technical Properties

• Molecular Class: D-Retro-Inverso (DRI) Peptidomimetic
• Primary Target: FOXO4-p53 Protein-Protein Interaction
• Research Application: Targeted apoptosis of senescent cells (Senolysis)
• Structure: L-Proline-enriched D-isomer sequence for enzymatic resistance