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S-1 is a synthetic 31-amino acid polypeptide and a long-acting analog of the endogenous incretin hormone. It exhibits 94% structural homology to human GLP-1 but features three critical modifications: the substitution of alanine with alpha-aminoisobutyric acid (Aib) at position 8 to resist dipeptidyl peptidase-4 (DPP-4) degradation, the substitution of lysine with arginine at position 34, and the acylation of lysine at position 26 with a C18 fatty diacid chain via a PEG spacer. These modifications facilitate reversible binding to albumin, significantly extending its half-life to approximately 165 hours. Semaglutide functions as a potent GLP-1 Receptor Agonist (GLP-1RA), modulating glucose-dependent insulin secretion and suppressing glucagon release. Research applications include investigations into postprandial glycemic excursions, gastric emptying kinetics, and the activation of POMC/CART neurons within the arcuate nucleus to regulate satiety and energy homeostasis.

Properties

• Amino Acid Sequence: His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
• Chemical Formula: C187H291N45O59
• Molar Mass: 4113.58 g/mol
• CAS Number: 910463-68-2
• Purity: ≥98% (HPLC)