ARA 10

ARA-290 (ARA-10) is a synthetic 11-amino acid peptide derived from the B-helix of erythropoietin. Unlike endogenous erythropoietin, ARA-290 is a non-hematopoietic ligand that selectively targets the Innate Repair Receptor (IRR), a heterocomplex of the erythropoietin receptor and the CD131 beta-common receptor. Research applications focus on the modulation of pro-inflammatory cytokine signaling and the investigation of neuroprotective pathways in models of peripheral neuropathy. This reagent is utilized in laboratory settings to study the attenuation of metabolic stress and the stabilization of cellular homeostasis without stimulating erythropoiesis.

Technical Properties

• Amino Acid Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
• Molecular Formula: C51H78N16O21
• Molar Mass: 1251.27 g/mol
• CAS Number: 1208240-54-5