AIC-R

AICAR (Acadesine) is a synthetic analog of adenosine monophosphate (AMP) and a critical intermediate in the de novo purine biosynthesis pathway. It functions as a cell-permeable allosteric activator of AMP-activated protein kinase (AMPK). By mimicking the action of endogenous AMP, AICAR is used in laboratory settings to investigate cellular energy homeostasis, glucose transport kinetics, and the regulation of fatty acid oxidation. Research applications focus on the modulation of metabolic signaling networks, mitochondrial biogenesis, and the interrogation of AMPK-dependent pathways in models of metabolic dysfunction and cellular stress.

Technical Properties

• Chemical Name: 5-Aminoimidazole-4-carboxamide ribonucleoside
• Chemical Formula: C9H14N4O5
• Molar Mass: 258.23 g/mol
• CAS Number: 2627-69-2 (Riboside) / 3031-94-5 (Ribotide/ZMP)