AHK

AHK-Cu is a synthetic copper-binding tripeptide (L-Alanyl-L-Histidyl-L-Lysine Cu2+) designed to investigate localized cellular repair and extracellular matrix (ECM) remodeling. Structurally related to GHK-Cu, AHK-Cu is specifically characterized by its influence on dermal papilla cells and vascular endothelial growth factor (VEGF) expression. It operates as a signaling modulator, facilitating copper-dependent enzymatic processes such as collagen cross-linking via lysyl oxidase. Research applications include investigations into the modulation of hair follicle cycles, the stimulation of type I collagen synthesis by fibroblasts, and the regulation of angiogenic signaling pathways in endothelial cell models.

Properties

• Amino Acid Sequence: Ala-His-Lys (complexed with Copper II)
• Chemical Formula: C15H24ClCuN6O4
• Molar Mass: 451.39 g/mol
• CAS Number: 682809-81-0
• Synonyms: Copper tripeptide-3, Alanine/Histidine/Lysine Polypeptide Copper HCl