5AM

5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable, selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme that plays a critical role in cellular energy homeostasis by catalyzing the methylation of nicotinamide, which can lead to the depletion of intracellular NAD+ levels. By inhibiting NNMT, 5-Amino-1MQ facilitates the preservation of NAD+ pools and increases the activity of the sirtuin-1 (SIRT1) pathway. Research applications include investigations into metabolic regulation, white adipose tissue signaling, muscle stem cell (satellite cell) regeneration, and the modulation of energy expenditure in models of obesity and metabolic dysfunction.

Properties

• Chemical Name: 5-amino-1-methylquinolin-1-ium
• Chemical Formula: C10H11N2+ (often supplied as an Iodide salt: C10H11IN2)
• Molar Mass: 159.21 g/mol (cation) / 286.11 g/mol (iodide salt)
• CAS Number: 42464-96-0 (Iodide salt) / 685079-15-6 (Cation)
• Solubility: Soluble in DMSO; limited solubility in water.